INFLUENCE OF HLA MATCHING ON THE EFFICACY OF ALLOGENEIC MESENCHYMAL STROMAL CELL THERAPIES FOR OSTEOARTHRITIS AND DEGENERATIVE DISC DISEASE

Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease

Background.The necessity for more effective therapies for chronic osteoarticular diseases has led to the development of treatments based on mesenchymal stem cells (MSCs), the natural precursors of musculoskeletal tissue.Treatments with autologous MSCs yielded excellent results, with nearly 70% improvement of pain and disability in osteoarthritis an

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Assessment of the structural and functional characteristics of human mesenchymal stem cells associated with a prolonged exposure of morphine

Abstract The discovery of the expression of opioid receptors in the skin and their role in orchestrating the process of tissue repair gave rise to questions regarding the potential effects of clinical morphine treatment in wound healing.Although short term treatment was reported to improve tissue regeneration, in vivo chronic administration was ass

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